Where to put the apostrophe

Q1.
She is John Wright, our general manager's secretary.
She is our general manager, John Wright's secretary.

Q2.
the vice-president of marketing and accounts' secretary

RULES cited from grammar books

(1) Possessives with Appositive Forms
When a possessive noun is followed by an appositive, a word that renames or explains that noun, the apostrophe +s is added to the appositive, not to the noun. When this happens, we drop the comma that would normally follow the appositive phrase.
(2) Possessives & Compound Constructions
Generally, the apostrophe -s is simply added to the end of the compound structure: a friend of mine's car. If this sounds clumsy, use the "of" construction to avoid the apostrophe: the car of a friend of mine, etc.
(3) Possessives of Plurals
Most plural nouns already end in s. To create their possessive, simply add an apostrophe after the s.

你設寫法很有問題，試以下分析
Q1
She is John Wright, our general manager's secretary.
這樣's和分段的話
句子的意思是
她的名字叫John Wright，是我們總經理的秘書
而不是總經理的名字叫John Wright
所以句子傳遞一個錯的訊息和人物資料錯誤

She is our general manager, John Wright's secretary.
這樣的's和分段的話
句子的意思是
她是我們的總經理，又是John Wright的秘書
所以她有兩個身份，而John Wright的職位竟要一個總經理作為秘書。邏輯上很難講得通

Q2
the vice-president of marketing and accounts' secretary
是可以這樣's的

不過綜合以上會產生的問題

最理想的寫法甚至講法都會是：

She is the secretary of John Wright, our general manager.

She is the secretary of the vice-president of marketing and accounts.

不要煩惱自尋了。