is Celecoxib a acidic or basic drugs?
Based on the fact that celecxib has a pyrazole group (with amines of the second and third type) and sulfonamide
回答 (2)
Refer to the diagram below. The lone pairs of electrons (shown as red dots) on the N atoms can act as Bronsted-Lowry base to accepted protons (hydrogen ions). Therefore, Celecoxib as a basic drug.
yes. pyrazole group is a basic compound but be aware that The sulfonamide is an acidic functional group. the aryl sulfonamides are weak acids. The acidic nature results from the ability of the SO2 moiety to stabilize the nitrogen anion through resonance, so lone pairs of electrons exist in sulfonamide do not react with hydrogen and d not have basic property.in many articles i found that celecoxib is a weak acidic drug.
收錄日期: 2021-04-24 01:09:09
原文連結 [永久失效]:
https://hk.answers.yahoo.com/question/index?qid=20180718130141AA3yAlh
檢視 Wayback Machine 備份