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The desire to triumph over our own mortality is an ancient dream,but it hardly stands alone. Whether we look at today's manipulations of our bodies by face-lifts, tattoos, pierced ears or erythropoietin, the same message rings loud and clear: if medicine one day enables us to manipulate our biology in appealing ways,many of us will do so—even if the benefits are dubious and the risks not insignificant. To most people, the earliest adopters of these technologies will seem reckless or crazy,but are they so different from the daredevil test pilots of jet aircraft in the 1950s? Virtually by definition, early users believe that the possible gains from their bravado justify the risks. Otherwise, they would wait for flawed procedures to be discarded, for technical glitches to be worked through, for interventions to become safer and more predictable. In truth, as long as people compete with one another for money,status, and mates, as long as they look for ways to display their worth and uniqueness,they will look for an edge for themselves and their children.