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Diabetes are metabolic disorders characterized by dysregulation of blood glucose levels. Diabetic retinopathy is the most serious sight-threatening complication of diabetes . Although our understanding of the pathogenesis of diabetic retinopathy has improved, and medical and surgical treatments have advanced, the long-term outcome of diabetic retinopathy remains poor. Therefore, there is a continuing need to search for a new modality for preventing and treating this debilitating complication.

The hyperglycemia that occurs in diabetes increases the production of reactive oxygen species (ROS) and depletes cellular antioxidant defense capacities, resulting in enhanced oxidative stress. Chronic oxidative stress is considered one of the primary causes of diabetic retinopathy . The retina has a high content of unsaturated fatty acids and high oxygen uptake, which increases lipid oxidation and ROS production. This is commonly thought to make the retina more vulnerable than any other tissue to oxidative stress damage