The odds are one in 292.2 million, which means you’re very unlikely to win. You are a lot more likely to be struck by lightning than you are to win the lottery: your chance of being struck by lightning in a year is about one in 960,000.
But as many lottery officials often say, "You have no chance of winning if you don’t participate at all."
In case you still want to give it a go, here is a website that explains how to improve your chances at winning:
http://www.insideedition.com/headlines/13922-heres-how-you-could-increase-your-chances-of-winning-tonights-450-million-powerball-jackpot
P.S. the luckiest numbers are 4, 8, 15, 16, 23, and 42 (all Lost fans will get this)