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Cougars will attack from behind, if they do attack, and it will be very difficult to defend yourself in that case. If you attack the cougar from behind, you would have a better chance. It would probably escape.
I did read of a man who was hunting wild turkey, he was lying down in full camouflage and blowing a turkey call, and a cougar pounced on him, thinking he was a turkey. He yelled and thrashed and struck the cat with his elbows, and it ran away. Case of mistaken identity.
Cougars, like most cats, do not like a confrontation. If you see it first, it won't attack you. Unless it thinks you are a threat to its cubs. If you see one stalking your child in the yard, yell and chase it away.
If you make noise while traveling through cougar country, the cougars will generally get out of your way.
But running away from one is worse than useless. Running will stimulate the predatory instinct. Face the cat, stand tall, and scream at it.