How do I get rid of the empty feeling?

I feel like all I can think about is how worthless I am and how much I don't deserve to live. Relationship issues are definitely a part of it, but no, they're not all of it. I've been diagnosed with depression and anxiety and put on medication, but I feel like it never goes away, even then I'm in the best situations.

I've had my hormones checked to be sure it's not that, and I've gone to several behavioral psychologists.

I have friends. I know I do. But with all my friends, even those that have been there for me since as long as I can remember, I can't help but wonder if they're being honest or if they're harboring some kind of hate.

I've tried starving. I've tried exercise. I've tried getting a hobby. I've tried sleep. I've tried talking. I've tried music.

I feel like there's no hope for me to feel better. Can somebody please help me?