What is the Antibody E?

The E antigen is one of the antigens in the Rhesus system. The Rhesus factor is the "positive or negative" listed after your ABO blood group and refers to the D antigen in the system. You are Rh positive if your red cells carry the D antigen.

There are other antigens in the Rhesus system that are clinically important and E is one of them.

In one of your transfusions you received blood with the E antigen on the red cells and your body created antibodies in response to that antigen. Now that your body is sensitized to the E antigen you could have a very severe reaction if you are transfused with E positive blood again. The antibodies you created previously will "attack" the transfused cells.

The card alerts the hospital to only transfuse you with E negative blood from now on.

E antibodies can also cause problems in pregnancy if the child is E positive ( inherited from the father) and your E antibodies enter the child's bloodstream.

https://en.wikipedia.org/wiki/Rh_blood_group_system

There are more blood groups than A, B, AB, and O. E is one of those smaller blood groups. In order to have developed an antibody to the E blood group, that means your wife and daughter don't possess the E antigen on their red blood cells. They have been exposed to the E antigen by transfusion (most likely), and because their bodies did not recognize it, their immune systems developed antibodies against it. This won't cause any immediate problems, however, if they ever need a transfusion again, the blood they recieve must not only be ABO compatible, it must be negative for the E antigen as well. Otherwise, the E antibodies will attack the donor blood and destroy it. Luckily, before recieving blood, the blood bank does an antibody screen and ID and will know to test the transfused blood for the E antigen. E negative blood is not rare and is usually always available.

Actually antibodies are large Y-shaped proteins and they are recruited by the immune system to recognize and neutralize foreign objects like bacteria and viruses. Antibody E or IgE has been found only in mammals. IgE also plays an essential role in type I hypersensitivity and IgE binds to allergens and triggers histamine release from mast cells and basophils, and is involved in allergy. Also protects against parasitic worms.

I really am not understanding. The only thing I can think to tell you is that your body has five different types of antibodies and one of them is called type E and it's the main antibody involved in allergic reactions. All five are - IgA, IgG, IgE, IgD, and IgM. Don't worry about what the "Ig" stands for. It's just the scientific name for antibodies.

Other than that I don't know what you want to know. Maybe more specifics about what the card says?

hi holly,
I don't know the exact answer to this question but I hope I can help out with it :)
An antibody, also known as an immunoglobin, is a large Y-shaped protein produced by B-cells that is used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, called an antigen.
Let's check out the definition of antibody E, the big E antibody.
definition: "antigens are small molecules or substances recoginized by the immune system.
Individuals typically inherit antigens, or sometimes aquire them during blood transfusions or childbirth. Blood antigens attach to the surface of red blood cells."
The Rh blood group is composed of 50 known blood antigens, such as D, C,c, E, and e.
The "E" antigen, also referred to as the "Big E," is a particularly strong antigen that poses an increased health risk during childbirth and blood transfusions.
The "Big E" antigen is significant because it can cause increased health risks for certain individuals. If an individual has the "E" antigen, he or she will not produce an "anti-E" antibody. In this case, the individual's immune system will tolerate the antigen. However, if the individual does not have the "E" antigen during exposure to it via childbirth or blood transfusion, the individual's immune system may build antibodies against it. This immune system response leads to potential complications such as hemolytic anaemia (red blood cell destruction) or infection.
If you want to know more about antigens and E antigen, you can click on the second link below at the source.
Hope it helped, and may the force be with you.

kind regards,
Lilyevangeline,
Jedi Sage, Council of Reconcilation