If you don't reply an email, it means three things: 1) You're unimportant, and I did not read your email (Trash immediately). 2) I'm a little busy and then missed your email. 3) You read the email but do not want to reply. #1 tells me that you show no respect to a human being. #2 is totally fine. Everyone has his/her priorities. #3 tells me that you don't know how to handle/build business relationship or deal with people. How hard is it to reply an email seriously?
更新1:
I agree with you on that. But, I forgot to say that the sender and recipient know each other but not close.