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JKD sidekicks tend to be more directed toward knees and used to either block the opponent's kick or advancement, or to hyperextend their knee. The JKD kick isn't chambered deeply and is used as a speed strike rather than a power strike. (Of course this is debated and altered by many JKD practicioners, but I'm speaking in general terms.) Also, the JKD side kick is frequently used to "close the gap" striking low and quick but landing closer to the opponent in order to move from a long-range to a close-range combat position.
I can't speak specifically to Karate, but TKD sidekicks are more commonly chambered deeply and thrown straight or even slightly upwards to the center mass (chest, ribs, and even head sometimes). They are a punishing blow because of the crushing power that is developed and broken ribs are not uncommon when a properly chambered TKD sidekick is used effectively. The kick is slower and more powerful, but it has versatility in the fact that it is used as a spinning kick, a flying kick, or an advancing kick.