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Using the top end, for an FHA loan (which has the lowest down payment), you will have to save $4,900 for the down payment alone. You will also need to save between $4,200 and $7,000 for the closing costs (3 to 5% is normal). So, a minimum of $9,100 and possibly closer to $11,900. You will receive a Good Faith Estimate when you are in the actual application process which will give a closer figure for the closing costs.
You pay for the house by sending a check each month. Now, if you want to know how much the payments are, there are a multitude of mortgage payment calculators on the web - I use the one at bankrate.com Just remember that the mortgage calculators only figure Principal and Interest, you will still need to add in taxes, homeowners insurance and if you go with a less than 20% down payment, PMI. This can add $200 or more to the payment.
Bankrate.com also has mortgage affordability calculators that you may want to check out.