What was the best for humans as a whole?

As a whole? That's easy!
1. Most hominids since the Acheulean have used fire, and that began 1.7 million years ago! By definition, every single human group ever has controlled fire, since fire was discovered before humans existed.
2. There were no wheels in the Americas before 1492 (except maybe as kid's toys). Despite this lack, the people managed just fine to move long distances and construct monumental architecture.
3. Although today pretty much everyone eats food from domesticated sources, this was not the case as little as 12,000 years ago. That seems like a long time, but not when you consider that humans have been around for something like 150,000 years! So we've only been eating domesticated food for 10% of our history (and not everyone eats domesticated food even now).

For all humans everywhere, fire was the best. There is even some evidence to suggest that the use of fire led to the initial stages of plant domestication, by clearing away brush allowing for wild cereals to grow. Kind of like modern slash-and-burn agriculture.

animals and plants.
without fire we can still eat raw meat and vegetables,
no wheel would mean no major civilization but we would still be here in some form just not as organized.

Fire

I would think fire also.

The domestication of animals and plants are necessary for human survival. The others are for human progress and convenience. Without the domestication of the dog, half the human population would have starved long ago.

3. was more important in terms of our technological advancement (Agriculture being more important than Transportation).

fire
without fire we wouldn't have the flamethrower

The discory of fire, the invention of the wheel, and the domestication of animals and plants.