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The spelling differences only seem to you to be acute; actually they are rather benign. Try sounding the similar, but different spellings, and you get a small, if any, difference. I realize that in , especially oriental languages, the slightest change in utterance of a sound can give the sound a different meaning. Not so true in English, where contextual usage has more control over meaning that does the sounding of a word.
It's hardly possible, to sound out the word "colour" without getting the same sound as that in "color". Americans pronounce the words "centre" and "center" the same ( "centre" is a French spelling, however, and would be pronounced in Quebec or Paris as "sawn-tr")
America's emancipation from Britain gave us a chance to make changes in spelling of words, and the writers of dictionaries had a ball!