haloalkane2

2008-10-07 3:28 am
You are given the task of preparing 2-methyloxypropane by on e of the reactions shown below. Which reaction would you choose? Explain your choice.
(a) (CH3)2CHONa + CH3Br --> (CH3)2CH一O一CH3 + NaBr
(b) (CH3)2CHBr + CH3ONa --> (CH3)2CH一O一CH3 + NaBr

答案話(b) (CH3)2CHBr 有steric hinderance,所以會slower
但係(CH3)2CHONa唔會有steric hinderance咩?

回答 (1)

2008-10-07 10:53 am
✔ 最佳答案

The answer is INCORRECTION. Steric hindrance is NOT the answer of the question.

In the two reactions, the sodium alkoxides ((CH3)2CHONa and CH3ONa) can act as both nucleophiles to cause nucleophilic substitution (SN reaction) and bases to cause elimination (E reaction).

In (1), the reactant is CH3Br, which has only one C atom in each molecule, can only undergo SN­ reaction but NOT E reaction. There is no elimination product, and only substitution product is formed.
SN: (CH3)2CHONa + CH3Br → (CH3)2CH-O-CH3 + NaBr

In (2), the reactant is (CH3)2CHBr, which is a secondary bromoalkane, can undergo both SN reaction and E reaction. There is a significant amount of elimination product, which may even be the major product.
SN: (CH3)2CHBr + CH3ONa → (CH3)2CH-O-CH3 + NaBr
E: (CH3)2CHBr + CH3ONa → CH3-CH=CH3 + CH3OH + NaBr

Due to the presence of elimination reaction in (2), (1) is a better choice for obtaining the substitution product, (CH3)2CH-O-CH3.
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