note that a^2-b^2=(a+b)(a-b) this is called the difference of squares rule
in this case a=a^2 and b=9
=>x^4-81=(a^2+9)(a^2-9)
again a^2-9 can be simplified using the difference of squares rule. so a^2=(a+3)(a-3)
putting these together:
x^4-81=(a^2+9)(a+3)(a-3)
it's easy! even i can do it!