To get to the answer, think about how these two parts would go together in a form of (ax - by)(ax + by).
One is plus and the other minus because the middle terms will have to cancel out because you have no middle term in
4x^2 - 25y^2
Now what squared is 4? 2
What squared is 25? 5
So you can see that you have to have a = 2 (because the 4 is with the x) and b = 5 (because the 25 is with the y).
Then the answer is: (2x - 5y)(2x + 5y)
When you multiply this out (using foil), you will get:
4x^2 -10xy + 10xy - 25y^2
See here that the middle terms cancel out, which is what we want.