地中海貧血 - 隔代遗传?

2008-06-03 8:18 am
请问会有可能父母都没有地中海貧血, 而下一代有呢?有没有隔代遗传这回事?

我被診斷为輕度α地中海貧血:
MCV: 67.6 / MCH: 21.2 / RBC Count: 5.43 / Haemoglobin: 10.9

而我的哥哥姐姐,跟父母也没有.........

Thank you!
更新1:

Thks for ur prompt & detailed response. What actually draws my concern is that none of my parents nor siblings are diagnozed with such disease, talking about it's relating to genes - does it interpret that I'm not a "born" member of the family?? Am I over-thinking too much??

回答 (3)

2008-06-05 7:23 am
Thank you whitebloodfish. Just out of curiosity - but one thing for sure, that my love and care to my parents would never change......
2008-06-04 7:22 pm
雖說地中海貧血大部分是遺傳造成,但地中海貧血本身也可以是由自體的血紅素基因後天變異而產生(英文是 de novo mutations)。所以不要只因為這樣一個因素而想得太多。
2008-06-03 9:13 pm
Base on the information that you have given, I can tell you that your doctor is right. You are anemic. The normal result varies from laboratory to laboratory, but the ranges are about the same. These are the normal ranges I refer to in Canada.

MCV: 80-100 um^3
MCH: 27-31 pg/cell
RBC: 4.6-6.2 x 10^6 cells/uL (male), 4.2-5.9 x 10^6 cells/uL (female)
Hemoglobin: 13-18 g/dL (male), 12-16 g/dL (female)

Thalassemia is a genetic blood disorder. That means it is something that you can prevent. It is something that your parent(s) have passed on to you. Your parent(s) may be carrier of the disorder. He/she may not show signs of the disorder but for sure he/she have it in his/her genes. The problem with thalassemia is your body is not producing enough protein (alpha and beta) to produce an efficient amount of hemoglobin. So taking iron pills will not help and please do not take any iron supplement without your doctor’s advice. Iron is not a water-soluble minerals, thus it will accumulate in the body and cause harm if overtaken. There two types of thalassmia: alpha thalassemia and beta thalassemia. Treatments will depend on which type you have. Generally eating a healthy meal with appropriate exercise will do you many goods to boost up your energy.

Hope this help.

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