麻煩英文好的或是化學好的人能夠幫忙翻譯這短文 感恩
An interesting phenomena observed in this study was that compound1 was unstable under acidic conditions.
Although compound 1 was stable in CD3OD and C6D6, when it was dissolved in an old sample of CDCl3 for a 1H NMR experiment,
the spectrum showed the presence of a mixture of 1 and 2 even after a short period of time.
Presumably the trace amounts of DCl formed on storage of CDCl3 catalyzed the transesterification reaction in 1.
Given this observation, it is not possible to state unambiguously that both 1 and 2 are natural products, since conceivably one could have been converted to the other during extraction in Madagascar or during shipment to the USA and storage.
All the isolated compounds were tested for antiproliferative activity against the A2780 human ovarian cancer cell line.
It was found that 1 and 2 showed mild antiproliferative activity with IC50 values equal to 10 and 36 μM,
respectively. Compounds 3 and 4 did not show any significant antiproliferative activity, and both had IC50 values greater than 60 μM.
It was previously reported that some cassane diterpenoids that had similar structures to the compounds isolated in our work showed moderate cytotoxicity against several cancer cell lines.6
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