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Prochlorperazine (marketed under the names Compazine, Buccastem, Stemetil and Phenotil) is a drug that belongs to the phenothiazine class of antipsychotic agents that are used for the treatment of nausea and vertigo. It is also a typical antipsychotic drug and a highly potent neuroleptic, 10 to 20 times more potent than chlorpromazine.
Due to the short duration of treatment it is usually well tolerated. It shares in general all side effects of chlorpromazine,but these are seen less frequently so and are less disturbing to thepatient, particularly as most patients with the aforementionedconditions are hospitalized. In the treatment of nausea/emesis it mightbe given together with an antiparkinsonian drug to prevent extrapyramidal side effects of prochlorperazine.
Some individuals are inherently allergic to this medicine. This medicine is known to produce seizuresand seizure-like symptoms in individuals who might not have had priorseizures. In such cases, contact health-care facilities for immediateattention. Long-term delays might lead to long-term effects. In extremecases, it has been known to produce permanent damage to the lower jawand the jaw joint due to extended seizure symptoms.
If treating psychotic conditions on a long-term basis, the high incidence of early and late (tardive dyskinesia)extrapyramidal side effects should be considered carefully.Prochlorperazine has in the long-term treatment approximately the sameincidence and severity of extrapyramidal side effects as haloperidol.