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Your cat is stressed. You said that you started a new job and your sister is at your home with your three children and your two....
Cats do not like change. You can purchase a Product called Feliway which is a spray and follow the directions. It has natural pheromones which will calm the cat down. It takes a few days to be effective.
You have to make sure that none of the children are chasing or scaring or grabbing your cat in a non gentle way; this can cause cats to become anti-social also.
If the behavior improves slightly, you can also get a plug in version of the pheromones which is called Comfort Zone.
There is another product which is all natural called Rescue Remedy, and that can help also.
You can also help by leaving an item of clothing near one of your cats comfort spots so that she can have the comfort of your scent.
It is basically the pet version of Separation Anxiety.
Good luck and have a Merry Christmas.
參考: Life with four cats in our household and one dog. A couple of our cats are really affected by lack of sunlight in the winter time, and we have to use the plug in Comfort Zones in order to maintain feline happiness in the household.