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Chemoprevention
The concept that medications could be used to prevent cancer is an attractive one, and many high-quality clinical trials support the use of such chemoprevention in defined circumstances.
Daily use of tamoxifen, a selective estrogen receptor modulator (SERM), typically for 5 years, has been demonstrated to reduce the risk of developing breast cancer in high-risk women by about 50%. A recent study reported that the selective estrogen receptor modulator raloxifene has similar benefits to tamoxifen in preventing breast cancer in high-risk women, with a more favorable side effect profile.[41]
Raloxifene is a SERM like tamoxifen; it has been shown (in the STAR trial) to reduce the risk of breast cancer in high-risk women equally as well as tamoxifen. In this trial, which studied almost 20,000 women, raloxifene had fewer side effects than tamoxifen, though it did permit more DCIS to form.[41]
Finasteride, a 5-alpha-reductase inhibitor, has been shown to lower the risk of prostate cancer, though it seems to mostly prevent low-grade tumors.[42] The effect of COX-2 inhibitors such as rofecoxib and celecoxib upon the risk of colon polyps have been studied in familial adenomatous polyposis patients[43] and in the general population. In both groups, there were significant reductions in colon polyp incidence, but this came at the price of increased cardiovascular toxicity.
Symptom
Roughly symptom of cancer can be divided into three kinds:
Some symptom: Unusual lump or swelling ' Tumour) ,Bleed (hemorrhage) ,Pain and ulcer. Because tumour oppresses the surrounding area and organizes symptoms such as jaundice (jaundice) caused .
Symptom of the malignant transformation: Enlargement of lymph nodes, coughing, coughing the blood (hemoptysis) , the hepatomegaly (hepatomegaly) , the bone pains, the symptoms of fracture and nervous system that it influences taking place that the skeleton is shifted because of tumour. Though will present the phenomenon of pain in latter stage of cancer, pain is not often symptom taking place in malignant transformation.
Full-length symptom: The weight lightens, loses the appetite, the evil disease physique (cachexia) , sweat in a large amount ' Night sweat at night) , anaemia and following lacking proper care (paraneoplastic phenomena) in the body that the new lives of tumour cause systematically ,Such as the change of the thrombus or hormone.
Various symptoms are probably caused by other diseases in described above, cancer might not be the main reason for producing these symptoms, the precise reason still needs differential diagnosis (differential diagnosis) Examination.