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Hello!
I haven't taken Greyhound, however, I had had a 33-hour bus trip. Therefore, taking Greyhound is not a good idea.
Reasons:
1. Immobilze, cannot walk or move;
2. Uncomfortable;
3. Other passengers may take your luggages by mistake;
4. Smell, distribance or harrassment from other passengers;
5. Driver eaily fall asleep travelling on highway;
6. Limited toilet and meal time;
7. Traffic may be affected by the weather condition: snow, rain, hail, etc.
8. Car sickness;
9. Taking pictures from the car, the picture quality is not good because of the window reflexation.
Let me know which city you are going to visit. I may be able to give you some help
參考: Myself, US travelling experiences: San Franscico, LA. New York, Chicago, New Mexico, Florida, Colorado, etc.