✔ 最佳答案
you either use "is there any problem" or "are there any problems",
besides the "is there any problem," you normally use plural after the "any", e.g. "if you have any problems, you can talk to the person who's in charge. / if you have any questions, you should ask the teacher for help."
but dont mix that up with "anyone/anything etc.", they're different from "any problems".
參考: myself.