Traditionally, who is the subjective (nominative) form only. According to traditional Prescriptive grammar: who is a subjective pronoun (subject of the side clause), and whom is the corresponding objective pronoun (an object of the side clause). Whose is the possessive form, not who's which is a contraction. See also: English declension.
He is someone to whom I owe a great deal. ("I" is subject, "whom" (relating to "he") the object)
He is someone who is a great guy. ("who" is subject of the side clause)
He is someone whose help ended my despair. ("whose" is adjunct to help, the side clause's subject)
Whom is falling out of use in informal English (increasingly, especially in American English, in some formal situations as well). In such instances, who has replaced whom as both the subjective and objective form.
Whom remains in significant use following a preposition[citation needed] (see examples immediately below). In informal contexts, the preposition may instead be placed at the end (see preposition stranding), and the word who may be omitted where it is used as a relative pronoun. For example:
(relative, formal): He is someone to whom I owe a great deal.
(interrogative, formal): To whom did you give it?
(relative, informal): He is someone (who) I owe a great deal to.
(interrogative, informal): Who did you give it to?