心臟病
維基百科,自由的百科全書
(重定向自心臟病)
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本條目是關於疾病,心藏病亦可指一種撲克牌遊戲,參見心臟病 (遊戲)
心臟病用來概指影響心臟結構功能的疾病,常見的心臟病包括:
冠心病:由脂質沉積於動脈壁而引起的冠狀動脈粥樣硬化。
缺血性心臟病:心臟供血不足引起的疾病。
心血管病:包括高血壓、糖尿病、高膽固醇等影響心血管功能的疾病。
肺性心臟病:一種因肺部疾病或胸壁畸形而導致的右心衰竭的疾病。
遺傳性或先天性心臟病:遺傳導致的先天性心臟結構或功能異常。
炎性心臟病:如風濕性心臟病、病毒性心肌炎等。
Coenzyme Q10 (CoQ10) is a fat-soluble antioxidant that can regenerate vitamin E in the antioxidant network. For more than 20 years, CoQ10 has been used to treat and prevent diseases, especially heart diseases, Alzheimer, Parkinson, gum diseases, and breast cancer. CoQ10 is also essential for the production of energy and it is present in all cell membranes. In the mitochondria, CoQ10 is involved in the Krebs cycle to produce ATP. Without CoQ10, the body is not able to run optimally. CoQ10 is a type of antioxidant that can be synthesised by the body.
CoQ10 was discovered by Prof. Frederick L. Crane at the University of Wisconsin in 1957. The story began when he found a mysterious orange substance from the mitochondria of a cow's heart. Prior to this discovery, he assumed that the substance was related to A vitamins. It was then first identified by Dr Karl Folkers that the substance has vitamin B6 and B12 structures in 1958. Dr Folkers was the director of the Institute for Biomedical Research at the University of Texas at Austin. However, Dr Folkers was unable to continue his research to study the therapeutic effect of CoQ10 due to limited financial grant and the expensive cost in producing CoQ10 from cattle hearts.
Since then, the technology to produce CoQ10 was sold to the Japanese. During the late 1950s and 1960s, Japanese researchers did some experiments with CoQ10 to study its role in the body. In 1965, a Japanese physician first used CoQ10 to treat heart failure and produced satisfactory result. Heart failure is normally a condition that does not respond well to traditional treatment. It is a pity that Western researchers paid little attention to this CoQ10 breakthrough and firmly believed in open heart surgery to solve heart problems. And today, CoQ10 is widely used in Japan as a treatment for heart disease and gum disease.
Apart from that, Dr Folkers finally managed to continue his research in the University of Texas and produced impactful findings on how CoQ10 benefits many people. He laid the groundwork for numerous studies that showed promising treatment using CoQ10 for angina, heart failure and cardiomyopathy1,2,4. As such, Dr Folkers won many chemistry awards and received the President's Medal of Science in 1990. He passed away at the age of ninety-one in December 1997. Before his demise, Dr Folkers also participated in remarkable studies that reported success in using CoQ10 in the treatment of advanced breast cancer3.
[edit]Reference
1: Hanioka, T., Tanaka, M., Ojima, M., Shizukuishi, S., & Folkers, K. Effect of topical application of coenzyme Q10 on adult periodontitis. Molecular Aspects of Medicine. 1994; 15: 241-248.
2: Langsjoen, P. H., Folkers, K., Lyson, K., Muratsu, K., Lyson, T., & Langsjoen, P. Pronounced increase of survival of patients with cardiomyopathy when treated with coenzyme Q10 and conventional therapy. International Journal of Tissue Reactions. 1990; 12(3): 163-168.
3: Lockwood, K., Moesgaard, S., Hanioka, T., & Folkers, K. Apparent partial remission of breast cancer in "high risk" patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10. Molecular Aspects of Medicine. 1994; 15: 231-240.
4: Nakamura, R., Littaru, G. P., Folkers, K., & Wilkinson, E. G. Study of CoQ10 enzymes in gingiva from patients with periodontal disease and evidence for a deficiency of coenzyme Q10. Proceedings of the National Academy of Sciences. 1974; 71(4): 1456-1460.
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