Sulpiride Tablet

這隻精神科藥物用來做甚麼?
Sulpiride is a selective dopamine D2 antagonist with antipsychotic and antidepressant activity.
即係可以醫治精神病和抗抑鬱症


甚麼情況下使用這種藥物﹖
如果有人病精神病又可以食,有抑鬱病都可以食囉

毒性強﹖
Cautions:
Despite its relative selectivity for dopamine D2 receptors, adverse effects of sulpiride have not differed significantly from those of other neuroleptic agents in most studies; predominant adverse effects have been extrapyramidal reactions and sedation. Tardive dyskinesia has been reported; similar to other neuroleptics, sulpiride has been associated with neuroleptic malignant syndrome and cholestatic jaundice.

Clinical Applications:
Sulpiride is effective in the treatment of acute and chronic schizophrenia but does not appear to offer a significant advantage over other antipsychotic agents; it has also been investigated in Huntington's disease, duodenal ulcer, poor lactation, contraception, depression, and for the treatment of tardive dyskinesia. Further studies are needed to determine its ultimate role in these conditions.

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Dosing Information
Adult Dosage:
Intramuscular: Intramuscular doses of 600 to 800 mg daily have been administered in acute schizophrenia.

Oral: The recommended oral dose of sulpiride in the treatment of schizophrenia is 200 to 400 mg twice daily with gradual increases based on clinical response to a maximum of 1200 mg daily. However, effective doses have varied considerably in clinical studies, ranging from 200 to 3200 mg daily in 2 or 3 divided doses. Lower doses may be adequate in acute, untreated patients, whereas higher doses may be required for chronic, severely ill schizophrenic patients. Further studies are needed to define optimal doses of sulpiride in specific patient subgroups.

Dosage in Renal Failure:
Sulpiride is primarily excreted renally, and dose adjustments have been suggested in renal insufficiency. Bressolle et al (1989) recommended the following modifications during long-term sulpiride therapy: creatinine clearance 30 to 60 mL/minute - 70% of normal dose; creatinine clearance 10 to 30 mL/minute - 50% of normal dose; Dreatinine clearance of less than 10 mL/minute - 34% of normal dose. Alternatively the dosage interval can be prolonged by a factor of 1.5, 2, and 3, respectively

抗抑鬱藥，可以控制情緒。