The recommended dose is one 120-mg capsule by mouth with liquid at each main meal that contains fat.Take XENICAL during meals or up to 1 hour after a meal. If you occasionally miss a meal or have a meal without fat, you can omit your dose of XENICAL. Doses above 120-mg three times daily have not been shown to provide an additional weight-loss benefit.
XENICAL interferes with your body's absorption of some fat-soluble vitamins. Therefore, when you use XENICAL, you should take a daily multivitamin supplement that contains vitamins D, E, and K and beta carotene. Take your multivitamin once a day at least 2 hours before or after taking XENICAL, such as at bedtime.