Men at this stage are usually worrying about two things.... job and family (assume he is married). Stepping into age of 40, they will be very worry about the position they are in now, if the are still not in a relatively high position, they may be getting harder and harder to get into such position as people may think why u are still a junior after so many years. These men will usually has a lot of compliants about their job and work, and even they will said how unlucky they are, you should try to listen to them, be supportive to them, motivate them.
On the other side, family, since men at 40 should already spent a lot of effort in making living, so please take care all the issues at home, and provide a comfortable shelter for them.